Page, who also has a starring role in the Netflix series The Umbrella Academy, last appeared in a feature film with 2017's Flatliners.
Close to You stars Page as a transgender man named Sam who returns to his hometown for the first time since he transitioned.
As he travels home, Sam "runs into Katherine (Hillary Baack), a friend from high school with her own complicated life now, and feelings from their unresolved past begin to bubble to the surface," per an official synopsis.
Page was able to appear at the film festival even as the Screen Actors Guild remains on strike against the Alliance of Motion Picture and Television Producers (AMPTP) since Close to You is an independent production that received an interim agreement from the guild.
He was previously spotted joining striking actors on a picket line in New York City in August and separately shared photo and video of himself on picket lines the same week.
Page's new movie comes about three months after his memoir Pageboy was published in June. At TIFF, the actor says he believes his book has helped him connect with fans.
Page also told Entertainment Weekly over the weekend that the film was a "liberating" experience three years after he came out as transgender.
"The way I get to feel working now is far more embodied coming from that foundation, versus entering and not feeling that way. It's a huge shift. Doing something like this, complete improv, before, would've been close to impossible," he said.
Close to You does not yet have a scheduled release in the United States; the movie is also scheduled to premiere at Canada's Cinéfest Sudbury International Film Festival on Sept. 23.